RT Journal Article SR Electronic T1 The role of SGLT-2 inhibitors in managing type 2 diabetes JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 47 OP 58 DO 10.3949/ccjm.88a.20088 VO 88 IS 1 A1 Yumiko Tsushima A1 M. Cecilia Lansang A1 Vinni Makin YR 2021 UL http://www.ccjm.org/content/88/1/47.abstract AB Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are an exceptionally versatile class of medication, and their glycemic and nonglycemic benefits could help millions of patients with type 2 diabetes. Of note, they have been shown to improve cardiac and renal outcomes, much-needed benefits in patients with type 2 diabetes, who are at a higher risk for developing cardiac and renal dysfunction than those who do not have diabetes. The indications for SGLT-2 inhibitors may continue to expand as ongoing clinical trials provide more insight into these drugs.