PT - JOURNAL ARTICLE AU - Leonard H. Calabrese AU - Cassandra Calabrese TI - Baricitinib and dexamethasone for hospitalized patients with COVID-19 AID - 10.3949/ccjm.88a.ccc073 DP - 2021 Feb 01 TA - Cleveland Clinic Journal of Medicine 4099 - http://www.ccjm.org/content/early/2021/01/29/ccjm.88a.ccc073.short 4100 - http://www.ccjm.org/content/early/2021/01/29/ccjm.88a.ccc073.full AB - The glucocorticoid dexamethasone is the standard of care in critically ill patients with COVID-19 to suppress the inappropriately heightened inflammatory response (cytokine storm), but the Janus kinase inhibitor baricitinib combined with remdesivir has received emergency use authorization for the same indication. As of this writing, in a hospitalized patient with COVID-19 who has evidence of pneumonitis or hypoxia, we recommend using either regimen, but not both together. Both regimens have shown benefit in randomized controlled trials, but we cannot state with certainty that either is superior to the other, nor whether they should be used together. Further trials are underway.