PT - JOURNAL ARTICLE AU - Calabrese, Leonard H. AU - Lenfant, Tiphaine AU - Calabrese, Cassandra TI - Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition AID - 10.3949/ccjm.87a.ccc060 DP - 2020 Aug 26 TA - Cleveland Clinic Journal of Medicine 4099 - http://www.ccjm.org/content/early/2021/02/24/ccjm.87a.ccc060.short 4100 - http://www.ccjm.org/content/early/2021/02/24/ccjm.87a.ccc060.full AB - This review focuses on an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators.