RT Journal Article SR Electronic T1 Quetiapine for primary insomnia: Consider the risks JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 286 OP 294 DO 10.3949/ccjm.88a.20031 VO 88 IS 5 A1 Modesto-Lowe, Vania A1 Harabasz, Agata K. A1 Walker, Sophia A. YR 2021 UL http://www.ccjm.org/content/88/5/286.abstract AB The second-generation antipsychotic drug quetiapine (Seroquel) is increasingly being used off-label for treating insomnia in the general population, possibly to avoid standard medications with known addictive qualities and adverse side effects. However, evidence to support using it in this way is scant, and quetiapine is associated with weight gain and other metabolic effects. It must be used cautiously and with appropriate monitoring for adverse effects and abuse.