%0 Journal Article %A Simon R. Mucha %A Siddharth Dugar %A Keith McCrae %A Douglas Joseph %A John Bartholomew %A Gretchen L. Sacha %A Michael Militello %T Update to coagulopathy in COVID-19: Manifestations and management %D 2020 %R 10.3949/ccjm.87a.ccc024-up %J Cleveland Clinic Journal of Medicine %X Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality. Markedly elevated levels of D-dimer with normal fibrinogen levels are the hallmark laboratory findings of severe COVID-19–associated coagulopathy. Prophylaxis against venous thromboembolism is paramount for all hospitalized patients with COVID-19, with more aggressive prophylaxis and screening recommended for critically ill patients with D-dimer levels above 3.0 μg/mL. Point-of-care ultrasonography is the imaging method of choice for patients at high risk, as it entails minimal risk of exposing providers to the virus. %U https://www.ccjm.org/content/ccjom/early/2021/06/01/ccjm.87a.ccc024-up.full.pdf