PT - JOURNAL ARTICLE AU - Humberto K. Choi AU - Jorge Ataucuri-Vargas AU - Charlie Lin AU - Amanda Singrey TI - The current state of tobacco cessation treatment AID - 10.3949/ccjm.88a.20099 DP - 2021 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 393--404 VI - 88 IP - 7 4099 - http://www.ccjm.org/content/88/7/393.short 4100 - http://www.ccjm.org/content/88/7/393.full SO - Cleve Clin J Med2021 Jul 01; 88 AB - Nicotine addiction and dependence is a chronic relapsing disease driven by addiction to nicotine. Proactive treatment for all tobacco users, regardless of their readiness to quit, is recommended. First-line tobacco cessation medications include nicotine replacement therapy, bupropion, and varenicline. Comprehensive treatment with behavioral interventions and pharmacologic therapy increases success rates of smoking cessation. Although there are many popular alternative treatments, they should not replace or delay the use of known effective therapies.