PT - JOURNAL ARTICLE AU - Saket Saxena AU - Ardeshir Z. Hashmi TI - COVID-19 in older adults AID - 10.3949/ccjm.88a.ccc080 DP - 2021 Sep 16 TA - Cleveland Clinic Journal of Medicine 4099 - http://www.ccjm.org/content/early/2021/09/14/ccjm.88a.ccc080.short 4100 - http://www.ccjm.org/content/early/2021/09/14/ccjm.88a.ccc080.full AB - The impact of COVID-19 varies by age group, and it has become clear that individuals over 65 years are disproportionately impacted by COVID-19 both in terms of severity of illness and mortality. Atypical presentations in older adults may result from pathophysiologic changes during aging and immune dysregulation because of the cumulative impact of chronic comorbidities. Herein we review the different clinical presentations of illness for older adults, the unique challenges faced by this population, and strategies for treatment.