RT Journal Article SR Electronic T1 Discontinuing antidepressants: Pearls and pitfalls JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 18 OP 26 DO 10.3949/ccjm.89a.21020 VO 89 IS 1 A1 Samantha J. Zwiebel A1 Adele C. Viguera YR 2022 UL http://www.ccjm.org/content/89/1/18.abstract AB Stopping antidepressants can be challenging due to the high rate of discontinuation symptoms. Patients with antidepressant discontinuation syndrome (ADS) commonly experience insomnia, flu-like symptoms, mood disturbances, dizziness, and paresthesias, but a broad array of adverse effects is possible. Symptoms can last for days to months, and different symptoms have different durations. Patient education, identification of patients most at risk for developing symptoms, and a slow antidepressant taper or cross-taper are important steps in mitigating the risk of ADS and managing patient concerns about ADS. Tapers should be carried out over weeks to months. Discontinuation symptoms should be managed with restarting the prior dose of antidepressant and then tapering even more slowly, with additional symptomatic management as needed.