PT - JOURNAL ARTICLE AU - Tarek Souaid AU - Jonathan Taliercio AU - James F. Simon AU - Ali Mehdi AU - Georges N. Nakhoul TI - Anemia of chronic kidney disease: Will new agents deliver on their promise? AID - 10.3949/ccjm.89a.21100 DP - 2022 Apr 01 TA - Cleveland Clinic Journal of Medicine PG - 212--222 VI - 89 IP - 4 4099 - http://www.ccjm.org/content/89/4/212.short 4100 - http://www.ccjm.org/content/89/4/212.full SO - Cleve Clin J Med2022 Apr 01; 89 AB - Anemia is a well-known complication of chronic kidney disease, and its treatment remains a challenge. Although erythropoiesis-stimulating agents (ESAs) raise hemoglobin levels, their benefits appear to be limited to decreasing the number of blood transfusions needed and perhaps improving quality of life. The newly developed prolyl hydroxylase inhibitors (PHIs)—agents that increase endogenous erythropoietin production—promise to improve outcomes for patients with anemia of chronic kidney disease. Randomized controlled trials have found these drugs to be at least as effective as ESAs, and the drugs are used in other countries. However, PHIs have yet to be approved in the United States.