%0 Journal Article %A Rebecca H. Sunenshine %A L. Clifford McDonald %T Clostridium difficile-associated disease: New challenges from an established pathogen %D 2006 %J Cleveland Clinic Journal of Medicine %P 187-197 %V 73 %N 2 %X Clostridium difficile-associated disease (CDAD) can range from uncomplicated diarrhea to sepsis and even death. CDAD rates and severity are increasing, possibly due to a new strain. Transmission of C difficile occurs primarily in health care facilities via the fecal-oral route following transient contamination of the hands of health care workers and patients; contamination of the patient care environment also plays an important role. %U https://www.ccjm.org/content/ccjom/73/2/187.full.pdf