PT - JOURNAL ARTICLE AU - Rebecca H. Sunenshine AU - L. Clifford McDonald TI - <em>Clostridium difficile</em>-associated disease: New challenges from an established pathogen DP - 2006 Feb 01 TA - Cleveland Clinic Journal of Medicine PG - 187--197 VI - 73 IP - 2 4099 - http://www.ccjm.org/content/73/2/187.short 4100 - http://www.ccjm.org/content/73/2/187.full SO - Cleve Clin J Med2006 Feb 01; 73 AB - Clostridium difficile-associated disease (CDAD) can range from uncomplicated diarrhea to sepsis and even death. CDAD rates and severity are increasing, possibly due to a new strain. Transmission of C difficile occurs primarily in health care facilities via the fecal-oral route following transient contamination of the hands of health care workers and patients; contamination of the patient care environment also plays an important role.