TY - JOUR T1 - <em>Clostridium difficile</em>-associated disease: New challenges from an established pathogen JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 187 LP - 197 VL - 73 IS - 2 AU - Rebecca H. Sunenshine AU - L. Clifford McDonald Y1 - 2006/02/01 UR - http://www.ccjm.org/content/73/2/187.abstract N2 - Clostridium difficile-associated disease (CDAD) can range from uncomplicated diarrhea to sepsis and even death. CDAD rates and severity are increasing, possibly due to a new strain. Transmission of C difficile occurs primarily in health care facilities via the fecal-oral route following transient contamination of the hands of health care workers and patients; contamination of the patient care environment also plays an important role. ER -