RT Journal Article SR Electronic T1 Clostridium difficile-associated disease: New challenges from an established pathogen JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 187 OP 197 VO 73 IS 2 A1 Rebecca H. Sunenshine A1 L. Clifford McDonald YR 2006 UL http://www.ccjm.org/content/73/2/187.abstract AB Clostridium difficile-associated disease (CDAD) can range from uncomplicated diarrhea to sepsis and even death. CDAD rates and severity are increasing, possibly due to a new strain. Transmission of C difficile occurs primarily in health care facilities via the fecal-oral route following transient contamination of the hands of health care workers and patients; contamination of the patient care environment also plays an important role.