PT - JOURNAL ARTICLE AU - Hariri, Essa H. AU - Al Hammoud, Mazen M. AU - Nissen, Steven E. AU - Hammer, Donald F. TI - Primary and secondary prevention of atherosclerotic cardiovascular disease: A case-based approach AID - 10.3949/ccjm.89a.21103 DP - 2022 Sep 01 TA - Cleveland Clinic Journal of Medicine PG - 513--522 VI - 89 IP - 9 4099 - http://www.ccjm.org/content/89/9/513.short 4100 - http://www.ccjm.org/content/89/9/513.full SO - Cleve Clin J Med2022 Sep 01; 89 AB - Estimating the risk of atherosclerotic cardiovascular disease (ASCVD) is a daily challenge for clinicians and is crucial to tailoring preventive medical care and guiding shared decision-making. New imaging modalities and novel biomarkers allow for more accurate assessment of patient risk and minimize the risk of over- or undertreating patients. Major cardiovascular medicine societies have incorporated new diagnostic modalities in their guidelines to aid clinical decision-making for primary and secondary prevention of ASCVD. This review presents commonly encountered cases relevant to estimating and reducing ASCVD risk based on available guidelines and expert opinion.