RT Journal Article SR Electronic T1 Primary and secondary prevention of atherosclerotic cardiovascular disease: A case-based approach JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 513 OP 522 DO 10.3949/ccjm.89a.21103 VO 89 IS 9 A1 Hariri, Essa H. A1 Al Hammoud, Mazen M. A1 Nissen, Steven E. A1 Hammer, Donald F. YR 2022 UL http://www.ccjm.org/content/89/9/513.abstract AB Estimating the risk of atherosclerotic cardiovascular disease (ASCVD) is a daily challenge for clinicians and is crucial to tailoring preventive medical care and guiding shared decision-making. New imaging modalities and novel biomarkers allow for more accurate assessment of patient risk and minimize the risk of over- or undertreating patients. Major cardiovascular medicine societies have incorporated new diagnostic modalities in their guidelines to aid clinical decision-making for primary and secondary prevention of ASCVD. This review presents commonly encountered cases relevant to estimating and reducing ASCVD risk based on available guidelines and expert opinion.