TY - JOUR T1 - Steroids in the acutely ill: Evolving recommendations and practice JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 505 LP - 511 DO - 10.3949/ccjm.89gr.22002 VL - 89 IS - 9 AU - Stephen M. Pastores Y1 - 2022/09/01 UR - http://www.ccjm.org/content/89/9/505.abstract N2 - Critical illness-related corticosteroid insufficiency (CIRCI) is a state of systemic inflammation involving dysregulation of the hypothalamic-pituitary-adrenal axis, altered cortisol metabolism, and tissue resistance to corticosteroids. Many conditions may be associated with CIRCI, including sepsis, septic shock, acute respiratory distress syndrome, and severe community-acquired pneumonia. Recommendations and practice for diagnosing and treating this condition have evolved as information has emerged. Here, the author reviews the current thinking. ER -