PT  - JOURNAL ARTICLE
AU  - Pastores, Stephen M.
TI  - Steroids in the acutely ill: Evolving recommendations and practice
AID  - 10.3949/ccjm.89gr.22002
DP  - 2022 Sep 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 505--511
VI  - 89
IP  - 9
4099  - http://www.ccjm.org/content/89/9/505.short
4100  - http://www.ccjm.org/content/89/9/505.full
SO  - Cleve Clin J Med2022 Sep 01; 89
AB  - Critical illness-related corticosteroid insufficiency (CIRCI) is a state of systemic inflammation involving dysregulation of the hypothalamic-pituitary-adrenal axis, altered cortisol metabolism, and tissue resistance to corticosteroids. Many conditions may be associated with CIRCI, including sepsis, septic shock, acute respiratory distress syndrome, and severe community-acquired pneumonia. Recommendations and practice for diagnosing and treating this condition have evolved as information has emerged. Here, the author reviews the current thinking.