RT Journal Article
SR Electronic
T1 Steroids in the acutely ill: Evolving recommendations and practice
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 505
OP 511
DO 10.3949/ccjm.89gr.22002
VO 89
IS 9
A1 Stephen M. Pastores
YR 2022
UL http://www.ccjm.org/content/89/9/505.abstract
AB Critical illness-related corticosteroid insufficiency (CIRCI) is a state of systemic inflammation involving dysregulation of the hypothalamic-pituitary-adrenal axis, altered cortisol metabolism, and tissue resistance to corticosteroids. Many conditions may be associated with CIRCI, including sepsis, septic shock, acute respiratory distress syndrome, and severe community-acquired pneumonia. Recommendations and practice for diagnosing and treating this condition have evolved as information has emerged. Here, the author reviews the current thinking.