RT Journal Article SR Electronic T1 The yin and yang of tumor necrosis factor inhibitors JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 251 OP 256 VO 73 IS 3 A1 Calabrese, Leonard YR 2006 UL http://www.ccjm.org/content/73/3/251.abstract AB Tumor necrosis factor (TNF) inhibitors have proven highly effective against a number of autoimmune diseases but have been disappointing in treating others. An increase in the risk of Mycobacterium tuberculosis and other opportunistic infections has been noted in patients treated with these agents. If we use these drugs, we need to weigh their beneficial and adverse effects.