PT - JOURNAL ARTICLE AU - Justin Hanks AU - Steven Fox AU - Omar Mehkri AU - Laura W. Lund AU - Tracey Dill AU - Abhijit Duggal AU - Sudhir Krishnan TI - On the horizon: Extracorporeal carbon dioxide removal AID - 10.3949/ccjm.89a.21084 DP - 2022 Dec 01 TA - Cleveland Clinic Journal of Medicine PG - 712--718 VI - 89 IP - 12 4099 - http://www.ccjm.org/content/89/12/712.short 4100 - http://www.ccjm.org/content/89/12/712.full SO - Cleve Clin J Med2022 Dec 01; 89 AB - Extracorporeal carbon dioxide removal (ECCO2R) uses mechanical systems to treat hypercapnic respiratory failure. Its utility has been investigated in acute respiratory distress syndrome (ARDS), acute exacerbations of chronic obstructive pulmonary disease (COPD), and status asthmaticus, and as a bridge to lung transplant. In this review, we discuss how it works, why it should help, and current evidence supporting its use.