RT Journal Article SR Electronic T1 On the horizon: Extracorporeal carbon dioxide removal JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 712 OP 718 DO 10.3949/ccjm.89a.21084 VO 89 IS 12 A1 Hanks, Justin A1 Fox, Steven A1 Mehkri, Omar A1 Lund, Laura W. A1 Dill, Tracey A1 Duggal, Abhijit A1 Krishnan, Sudhir YR 2022 UL http://www.ccjm.org/content/89/12/712.abstract AB Extracorporeal carbon dioxide removal (ECCO2R) uses mechanical systems to treat hypercapnic respiratory failure. Its utility has been investigated in acute respiratory distress syndrome (ARDS), acute exacerbations of chronic obstructive pulmonary disease (COPD), and status asthmaticus, and as a bridge to lung transplant. In this review, we discuss how it works, why it should help, and current evidence supporting its use.