PT  - JOURNAL ARTICLE
AU  - Nikita Ashcherkin
AU  - Archna A. Patel
AU  - Alicia Algeciras-Schimnich
AU  - Krupa B. Doshi
TI  - Bone turnover markers to monitor oral bisphosphonate therapy
AID  - 10.3949/ccjm.90a.22002
DP  - 2023 Jan 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 26--31
VI  - 90
IP  - 1
4099  - http://www.ccjm.org/content/90/1/26.short
4100  - http://www.ccjm.org/content/90/1/26.full
SO  - Cleve Clin J Med2023 Jan 01; 90
AB  - Bisphosphonates are widely used as first-line therapy to slow bone loss and decrease fracture risk in postmenopausal women with osteoporosis. Nonadherence to oral bisphosphonates diminishes the benefit of reduced bone loss and fracture risk of these medications. Strategies to enhance osteoporosis monitoring and adherence to therapy are crucial to improve outcomes. Dual-energy x-ray absorptiometry (DXA) is the gold standard for monitoring bone mineral density but is slow to detect change after initiation of oral bisphosphonate therapy. Bone turnover markers (BTMs) are by-products released during bone remodeling and are measurable in blood and urine. We review how the rapid change in BTMs can be a useful short-term tool to monitor the effectiveness of oral bisphosphonate therapy, which may ultimately improve adherence to therapy and outcomes.