TY - JOUR T1 - Smallpox and monkeypox: Looking back and looking ahead JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 141 LP - 144 DO - 10.3949/ccjm.90a.22067 VL - 90 IS - 3 AU - Paolo Sossai AU - Domenico Staiti AU - Massimiliano Cannas AU - Piero Grima Y1 - 2023/03/01 UR - http://www.ccjm.org/content/90/3/141.abstract N2 - The monkeypox (mpox) epidemic was declared a global health emergency in July 2022. The mpox virus belongs to the same virus family as the smallpox, or variola virus, but the infection is a less lethal threat than smallpox. Nevertheless, its relationship to smallpox is a worldwide concern, as is the discontinuation of universal smallpox vaccinations since the 1980s. Newer therapies and vaccines are available for both infections, including 2 antiviral drugs that can be used under certain conditions. Two vaccines have been developed for mpox prevention, but clarity is needed on when and how to use them. Preventive public health measures and prioritization of resources for managing infectious disease are concerns. ER -