RT Journal Article SR Electronic T1 Smallpox and monkeypox: Looking back and looking ahead JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 141 OP 144 DO 10.3949/ccjm.90a.22067 VO 90 IS 3 A1 Sossai, Paolo A1 Staiti, Domenico A1 Cannas, Massimiliano A1 Grima, Piero YR 2023 UL http://www.ccjm.org/content/90/3/141.abstract AB The monkeypox (mpox) epidemic was declared a global health emergency in July 2022. The mpox virus belongs to the same virus family as the smallpox, or variola virus, but the infection is a less lethal threat than smallpox. Nevertheless, its relationship to smallpox is a worldwide concern, as is the discontinuation of universal smallpox vaccinations since the 1980s. Newer therapies and vaccines are available for both infections, including 2 antiviral drugs that can be used under certain conditions. Two vaccines have been developed for mpox prevention, but clarity is needed on when and how to use them. Preventive public health measures and prioritization of resources for managing infectious disease are concerns.