RT Journal Article SR Electronic T1 Central sensitization, chronic pain, and other symptoms: Better understanding, better management JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 245 OP 254 DO 10.3949/ccjm.90a.22019 VO 90 IS 4 A1 Mary M. Volcheck A1 Stephanie M. Graham A1 Kevin C. Fleming A1 Arya B. Mohabbat A1 Connie A. Luedtke YR 2023 UL http://www.ccjm.org/content/90/4/245.abstract AB Central sensitization, a pathophysiologic process in which the central nervous system undergoes changes that alter its processing of pain and other sensory stimuli, may be the mechanism underlying various conditions in which patients have unexplained pain and fatigue. Patients frequently misunderstand the cause of their symptoms and pursue unnecessary evaluations and treatments. Clinicians have a pivotal role in decreasing this misunderstanding by providing patient education, which can affect perception, management, functional status, and quality of life.