PT  - JOURNAL ARTICLE
AU  - Jaroenpuntaruk, Valerie
AU  - Gray, Adam
TI  - Deadly drug rashes: Early recognition and multidisciplinary care
AID  - 10.3949/ccjm.90a.22043
DP  - 2023 Jun 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 373--381
VI  - 90
IP  - 6
4099  - http://www.ccjm.org/content/90/6/373.short
4100  - http://www.ccjm.org/content/90/6/373.full
SO  - Cleve Clin J Med2023 Jun 01; 90
AB  - Potentially deadly drug rashes include Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, and drug-induced vasculitis. Differentiating them can be a challenge. Factors to consider include timing of rash to drug exposure, rash distribution and clinical appearance, and the presence of systemic features such as mucosal involvement, organ failure, or eosinophilia. Various scoring systems aid in the diagnosis, but skin biopsy is the gold standard. Prompt identification and withdrawal of the suspected offending agent are the crucial first steps in management.