RT Journal Article
SR Electronic
T1 Deadly drug rashes: Early recognition and multidisciplinary care
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 373
OP 381
DO 10.3949/ccjm.90a.22043
VO 90
IS 6
A1 Jaroenpuntaruk, Valerie
A1 Gray, Adam
YR 2023
UL http://www.ccjm.org/content/90/6/373.abstract
AB Potentially deadly drug rashes include Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, and drug-induced vasculitis. Differentiating them can be a challenge. Factors to consider include timing of rash to drug exposure, rash distribution and clinical appearance, and the presence of systemic features such as mucosal involvement, organ failure, or eosinophilia. Various scoring systems aid in the diagnosis, but skin biopsy is the gold standard. Prompt identification and withdrawal of the suspected offending agent are the crucial first steps in management.