RT Journal Article
SR Electronic
T1 Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 439
OP 447
DO 10.3949/ccjm.90a.22093
VO 90
IS 7
A1 Aboseif, Albert
A1 Bireley, J. Daniel
A1 Li, Yuebing
A1 Polston, David
A1 Abbatemarco, Justin R.
YR 2023
UL http://www.ccjm.org/content/90/7/439.abstract
AB Postural orthostatic tachycardia syndrome (POTS)—sustained tachycardia upon standing without orthostatic hypotension—can be diagnosed clinically without an extensive diagnostic evaluation unless certain atypical features suggest an alternative diagnosis. A unifying pathophysiologic mechanism has not been identified, although several have been proposed. Similarities between POTS and various autoimmune disorders suggest an immune mechanism in a subset of patients. However, no causative antibody has been identified, and associated antibodies are rarely clinically relevant. Moreover, immunotherapies are not currently recommended for POTS, although clinical trials are underway to clarify their utility.