PT - JOURNAL ARTICLE AU - Haber, Lawrence A. AU - Dhaliwal, Gurpreet AU - Lo, Lowell AU - Rizzuto, Gabrielle TI - Evaluating a low anion gap: A practical approach AID - 10.3949/ccjm.90a.23035 DP - 2023 Oct 01 TA - Cleveland Clinic Journal of Medicine PG - 619--623 VI - 90 IP - 10 4099 - http://www.ccjm.org/content/90/10/619.short 4100 - http://www.ccjm.org/content/90/10/619.full SO - Cleve Clin J Med2023 Oct 01; 90 AB - In teaching and in practice, little attention is given to a low anion gap. This oversight can result in a missed opportunity to diagnose acute or chronic disorders requiring treatment. In this article, we review the constituents of the anion gap, build a differential diagnosis for a low anion gap using case examples, and provide a stepwise approach to diagnostic testing to evaluate this abnormal finding.