PT  - JOURNAL ARTICLE
AU  - W. H. Wilson Tang
TI  - Do thiazolidinediones cause heart failure? A critical review
DP  - 2006 Apr 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 390--397
VI  - 73
IP  - 4
4099  - http://www.ccjm.org/content/73/4/390.short
4100  - http://www.ccjm.org/content/73/4/390.full
SO  - Cleve Clin J Med2006 Apr 01; 73
AB  - Concern has been raised about whether the fluid retention caused by thiazolidinediones (TZDs, ie, rosiglitazone and pioglitazone) can cause or exacerbate congestive heart failure. Although fluid retention is a worrisome side effect of TZDs, current evidence does not link fluid retention caused by TZDs with worsening heart function. TZDs have many benefits for patients with diabetes and can even be used cautiously in patients with mild heart failure, with careful monitoring of volume status.