RT Journal Article
SR Electronic
T1 Do thiazolidinediones cause heart failure? A critical review
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 390
OP 397
VO 73
IS 4
A1 Wilson Tang, W. H.
YR 2006
UL http://www.ccjm.org/content/73/4/390.abstract
AB Concern has been raised about whether the fluid retention caused by thiazolidinediones (TZDs, ie, rosiglitazone and pioglitazone) can cause or exacerbate congestive heart failure. Although fluid retention is a worrisome side effect of TZDs, current evidence does not link fluid retention caused by TZDs with worsening heart function. TZDs have many benefits for patients with diabetes and can even be used cautiously in patients with mild heart failure, with careful monitoring of volume status.