RT Journal Article
SR Electronic
T1 Nonstatin therapy to reduce low-density lipoprotein cholesterol and improve cardiovascular outcomes
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 53
OP 63
DO 10.3949/ccjm.91a.23058
VO 91
IS 1
A1 Singh, Abhayjit
A1 Cho, Leslie S.
YR 2024
UL http://www.ccjm.org/content/91/1/53.abstract
AB Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality, with low-density lipoprotein (LDL) cholesterol being a causative risk factor. Though statins have a decades-long track record of efficacy and safety, nonstatin agents may be used to reduce LDL cholesterol as an adjunct or alternative to statin therapy. Several new nonstatin medications have been approved in recent years, with robust data from clinical trials supporting their use in atherosclerotic disease. This review addresses the indications, evidence, and important prescribing considerations for using nonstatin lipid-lowering therapy and proposes a practical approach for determining when to initiate nonstatin therapy.