RT Journal Article
SR Electronic
T1 Management of venous thromboembolism in patients with active cancer
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 109
OP 117
DO 10.3949/ccjm.91a.23017
VO 91
IS 2
A1 Dave, Heloni M.
A1 Khorana, Alok A.
YR 2024
UL http://www.ccjm.org/content/91/2/109.abstract
AB Venous thromboembolism (VTE) is a major health burden in patients with cancer, causing morbidity, emergency room visits, hospitalizations, and death. Treatment is challenging, as it is necessary to balance the risk of recurrent thrombosis and bleeding associated with anticoagulants. Treatment paradigms are shifting from low-molecular-weight heparin monotherapy. Multiple recent randomized controlled trials have demonstrated the safety and efficacy of direct oral anticoagulants in this setting. Current studies are evaluating factor XI inhibitors as potential treatments for cancer-associated VTE.