RT Journal Article
SR Electronic
T1 von Willebrand disease: A guide for the internist
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 119
OP 127
DO 10.3949/ccjm.91a.22033
VO 91
IS 2
A1 Kaur, Varinder
A1 Elghawy, Omar
A1 Deshpande, Saarang
A1 Riley, David
YR 2024
UL http://www.ccjm.org/content/91/2/119.abstract
AB von Willebrand disease (VWD), the most common inherited bleeding disorder, results when patients either do not make enough von Willebrand factor (VWF) or make defective VWF. The pathophysiology of this disorder is complex but needs to be understood to interpret the diagnostic tests. Most patients have mild to moderate symptoms and can be adequately counseled and managed by a general internist, but some need to consult a hematologist. We review the pathophysiology of VWD, its subtypes, common presentations of each subtype, diagnostic testing, and management of mild as well as severe clinical manifestations of VWD.