PT  - JOURNAL ARTICLE
AU  - Nachawi, Noura
AU  - Li, Dingfeng
AU  - Lansang, M. Cecilia
TI  - Glucocorticoid-induced adrenal insufficiency and glucocorticoid withdrawal syndrome: Two sides of the same coin
AID  - 10.3949/ccjm.91a.23039
DP  - 2024 Apr 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 245--255
VI  - 91
IP  - 4
4099  - http://www.ccjm.org/content/91/4/245.short
4100  - http://www.ccjm.org/content/91/4/245.full
SO  - Cleve Clin J Med2024 Apr 01; 91
AB  - Diseases of the adrenal glands can lead to primary adrenal insufficiency, and suppression of the hypothalamic-pituitary-adrenal axis can cause secondary adrenal insufficiency (adrenal suppression). The most common cause of adrenal suppression is exogenous steroids, a condition recently termed glucocorticoid-induced adrenal insufficiency (GIAI). Similarly, weaning from high doses of glucocorticoids or giving insufficient glucocorticoid replacement after curative surgery for endogenous hypercortisolism (Cushing syndrome) can lead to glucocorticoid withdrawal syndrome, which overlaps with GIAI.