RT Journal Article SR Electronic T1 Management of lower-extremity venous thromboembolism: An updated review JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 229 OP 235 DO 10.3949/ccjm.91a.22090 VO 91 IS 4 A1 Ziyadeh, Farah A1 Mauer, Yael YR 2024 UL http://www.ccjm.org/content/91/4/229.abstract AB According to the 2021 updated guidelines of the American College of Chest Physicians, the location of venous thromboembolism, the severity of symptoms, the risk of thrombus extension vs that of bleeding, and comorbidities all affect the decision to treat, the choice of anti-thrombotic agent, and the duration of therapy. In patients with isolated distal deep vein thrombosis without high-risk features, monitoring progression is recommended over initiating anticoagulation. However, treatment of proximal deep vein thrombosis with anticoagulation is strongly recommended by the guidelines. More evidence now supports the treatment of superficial vein thrombosis with anticoagulation in high-risk patients.