PT - JOURNAL ARTICLE AU - Wiser, Amy L. TI - Preexposure prophylaxis for preventing HIV infection: Routine practice in primary care AID - 10.3949/ccjm.91a.23079 DP - 2024 Jun 01 TA - Cleveland Clinic Journal of Medicine PG - 361--371 VI - 91 IP - 6 4099 - http://www.ccjm.org/content/91/6/361.short 4100 - http://www.ccjm.org/content/91/6/361.full SO - Cleve Clin J Med2024 Jun 01; 91 AB - An estimated 1.2 million people in the United States have human immunodeficiency virus (HIV) infection per US Centers for Disease Control and Prevention 2021 data. The highest risk of HIV transmission occurs during injection drug use with needle sharing and during sexual activity, most significantly in condomless, receptive anal intercourse. Preexposure prophylaxis (PrEP) for the prevention of HIV infection is part of a larger biobehavioral strategy that uses antiretroviral medication, an oral formulation taken daily or during anticipated exposure events, or an injectable formulation administered every 8 weeks. PrEP consists of 3 possible regimens: emtricitabine/tenofovir disoproxil fumarate, emtricitabine/tenofovir alafenamide, or injectable cabotegravir. Primary care clinicians are strategically positioned to provide PrEP education and access.