PT - JOURNAL ARTICLE AU - Jaswaney, Rahul AU - Sokoloff, Samantha AU - Rakita, Val AU - Rubin, Daniel J. TI - SGLT-2 inhibitors in heart failure and chronic kidney disease: A review for internists AID - 10.3949/ccjm.91a.23093 DP - 2024 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 415--423 VI - 91 IP - 7 4099 - http://www.ccjm.org/content/91/7/415.short 4100 - http://www.ccjm.org/content/91/7/415.full SO - Cleve Clin J Med2024 Jul 01; 91 AB - Despite current therapies, heart failure and chronic kidney disease continue to be major causes of morbidity and mortality. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have recently become standard-of-care therapy for these conditions. This review summarizes important randomized controlled trials of SGLT-2 inhibitors and guidelines for using these agents in patients with heart failure and chronic kidney disease in both clinic and hospital settings.