PT - JOURNAL ARTICLE AU - Schiavone, William A. AU - Majdalany, David S. TI - Don’t judge a book by its cover: Unusual presentations of pericardial disease AID - 10.3949/ccjm.92a.24065 DP - 2025 Feb 01 TA - Cleveland Clinic Journal of Medicine PG - 109--116 VI - 92 IP - 2 4099 - http://www.ccjm.org/content/92/2/109.short 4100 - http://www.ccjm.org/content/92/2/109.full SO - Cleve Clin J Med2025 Feb 01; 92 AB - The presentation of pericardial disease can be unusual, and what is assumed to be pericardial disease may not be. Knowing pericardial and mediastinal anatomy is vital for understanding these unusual presentations. This review focuses on the history, physical examination, and fundamental diagnostic testing, integrated with pericardial and mediastinal anatomy and pathophysiology.