RT Journal Article SR Electronic T1 Don’t judge a book by its cover: Unusual presentations of pericardial disease JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 109 OP 116 DO 10.3949/ccjm.92a.24065 VO 92 IS 2 A1 Schiavone, William A. A1 Majdalany, David S. YR 2025 UL http://www.ccjm.org/content/92/2/109.abstract AB The presentation of pericardial disease can be unusual, and what is assumed to be pericardial disease may not be. Knowing pericardial and mediastinal anatomy is vital for understanding these unusual presentations. This review focuses on the history, physical examination, and fundamental diagnostic testing, integrated with pericardial and mediastinal anatomy and pathophysiology.