PT - JOURNAL ARTICLE AU - Cornish, Nicole AU - Coles, Tara AU - Cheng, M. Jennifer AU - Sotomayor, Claudia Ruiz AU - Wolfgang, Aaron AU - Spevak, Christopher TI - Psychedelics, spirituality, and existential distress in patients at the end of life AID - 10.3949/ccjm.92a.24100 DP - 2025 Apr 01 TA - Cleveland Clinic Journal of Medicine PG - 248--254 VI - 92 IP - 4 4099 - http://www.ccjm.org/content/92/4/248.short 4100 - http://www.ccjm.org/content/92/4/248.full SO - Cleve Clin J Med2025 Apr 01; 92 AB - Psychedelic-assisted therapy clinical trials conducted over the past decade have prompted increased interest in the use of psychedelics to treat nonphysical suffering, which can include significant spiritual and existential distress at the end of life. The authors explore the role of psychedelics in helping to address patients’ spiritual and existential suffering from a medical, ethical, and legal perspective, with the aim of stimulating discussion and research on this timely and clinically promising topic.