RT Journal Article SR Electronic T1 Psychedelics, spirituality, and existential distress in patients at the end of life JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 248 OP 254 DO 10.3949/ccjm.92a.24100 VO 92 IS 4 A1 Cornish, Nicole A1 Coles, Tara A1 Cheng, M. Jennifer A1 Sotomayor, Claudia Ruiz A1 Wolfgang, Aaron A1 Spevak, Christopher YR 2025 UL http://www.ccjm.org/content/92/4/248.abstract AB Psychedelic-assisted therapy clinical trials conducted over the past decade have prompted increased interest in the use of psychedelics to treat nonphysical suffering, which can include significant spiritual and existential distress at the end of life. The authors explore the role of psychedelics in helping to address patients’ spiritual and existential suffering from a medical, ethical, and legal perspective, with the aim of stimulating discussion and research on this timely and clinically promising topic.