RT Journal Article SR Electronic T1 Migraine prophylaxis: Who, why, and how JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 793 OP 816 VO 73 IS 9 A1 Jadwiga Loj A1 Glen D. Solomon YR 2006 UL http://www.ccjm.org/content/73/9/793.abstract AB If a patient has frequent, severely debilitating migraine headaches, prophylactic treatment may help. Beta-blockers, tricyclic antidepressants, and anticonvulsants have the best evidence of efficacy; calcium channel blockers and nonsteroidal anti-inflammatory drugs are also popular because they are well tolerated and inexpensive. We review migraine treatment with emphasis on prophylaxis.