RT Journal Article
SR Electronic
T1 Direct oral anticoagulants: Challenging prescribing scenarios in everyday practice
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 353
OP 361
DO 10.3949/ccjm.92a.24061
VO 92
IS 6
A1 Bukhari, Syed
A1 Ghoweba, Mohamed
A1 Khan, Syed Zamrak
A1 Saati, Ammar
A1 Gomes, Marcelo
YR 2025
UL http://www.ccjm.org/content/92/6/353.abstract
AB Direct oral anticoagulants (DOACs) are preferred to vitamin K antagonists for treating venous thromboembolism and nonvalvular atrial fibrillation, primarily because of comparable efficacy, consistent dosing, and fewer drug-drug interactions. However, major trials that led to the approval of DOACs excluded subsets of patients who are challenging to treat in the primary care setting, including patients with extreme body weight, advanced kidney disease, and advanced cirrhosis, and those who have undergone bariatric surgery. The authors review the available evidence and outline current recommendations to help guide the appropriate use of DOACs in these patients.