PT  - JOURNAL ARTICLE
AU  - Ramsawak, Seshma
AU  - Cohen, Scott
AU  - Linares, Andrea
AU  - Cavanaugh, Corey
TI  - IgA nephropathy: Update on pathogenesis and treatment
AID  - 10.3949/ccjm.92a.24105
DP  - 2025 Jun 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 373--383
VI  - 92
IP  - 6
4099  - http://www.ccjm.org/content/92/6/373.short
4100  - http://www.ccjm.org/content/92/6/373.full
SO  - Cleve Clin J Med2025 Jun 01; 92
AB  - The pathogenesis of immunoglobulin (Ig) A nephropathy is described through a “4-hit” model involving production of galactose-deficient IgA, production of autoantibodies to galactose-deficient IgA, and subsequent deposition of immune complexes in the kidney glomerulus. Diagnosis remains dependent on a kidney biopsy, often after hematuria or proteinuria is detected on urinalysis. The cornerstone of therapy still involves renin-angiotensin-aldosterone system inhibitors or corticosteroids; however, new therapies targeting key aspects of the pathogenesis of IgA nephropathy are being introduced.