RT Journal Article
SR Electronic
T1 IgA nephropathy: Update on pathogenesis and treatment
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 373
OP 383
DO 10.3949/ccjm.92a.24105
VO 92
IS 6
A1 Ramsawak, Seshma
A1 Cohen, Scott
A1 Linares, Andrea
A1 Cavanaugh, Corey
YR 2025
UL http://www.ccjm.org/content/92/6/373.abstract
AB The pathogenesis of immunoglobulin (Ig) A nephropathy is described through a “4-hit” model involving production of galactose-deficient IgA, production of autoantibodies to galactose-deficient IgA, and subsequent deposition of immune complexes in the kidney glomerulus. Diagnosis remains dependent on a kidney biopsy, often after hematuria or proteinuria is detected on urinalysis. The cornerstone of therapy still involves renin-angiotensin-aldosterone system inhibitors or corticosteroids; however, new therapies targeting key aspects of the pathogenesis of IgA nephropathy are being introduced.