RT Journal Article SR Electronic T1 Contemporary management of peripheral arterial disease JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S38 OP S44 VO 73 IS 10 suppl 4 A1 Amjad AlMahameed A1 John R. Bartholomew A1 Teresa L. Carman A1 Bernardo B. Fernandez, Jr. YR 2006 UL http://www.ccjm.org/content/73/10_suppl_4/S38.abstract AB Intermittent claudication (IC) is the classic complaint associated with peripheral arterial disease (PAD) and can significantly limit a patient’s lifestyle and workplace abilities. IC is defined as reproducible pain affecting the muscles of the lower extremities that begins and increases with activity and resolves with rest. The clinical goals of management include increasing walking distance and improving quality of life. A dedicated, supervised walking program is the foundation of IC management. In addition, two drugs have been approved by the US Food and Drug Administration for the treatment of IC: cilostazol and pentoxifylline. Other agents and treatment strategies have been investigated, and some show clinical promise.