PT  - JOURNAL ARTICLE
AU  - Oren, Ohad
AU  - Singh, Abhay
AU  - Carraway, Hetty E.
AU  - Laffin, Luke J.
AU  - Nissen, Steven E.
TI  - Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
AID  - 10.3949/ccjm.93a.26003
DP  - 2026 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 289--295
VI  - 93
IP  - 5
4099  - http://www.ccjm.org/content/93/5/289.short
4100  - http://www.ccjm.org/content/93/5/289.full
SO  - Cleve Clin J Med2026 May 01; 93
AB  - Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition defined by somatic mutations in hematopoietic stem cells that result in clonal expansion, without overt hematologic malignancy. It is now recognized as a potent risk factor for atherosclerotic cardiovascular disease, with emerging associations across a broader spectrum of cardiovascular phenotypes, including myocarditis, pericarditis, arrhythmias, valvular heart disease, and heart failure. The authors of this article review the epidemiology, pathophysiology, and management of this condition.