RT Journal Article
SR Electronic
T1 Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 289
OP 295
DO 10.3949/ccjm.93a.26003
VO 93
IS 5
A1 Oren, Ohad
A1 Singh, Abhay
A1 Carraway, Hetty E.
A1 Laffin, Luke J.
A1 Nissen, Steven E.
YR 2026
UL http://www.ccjm.org/content/93/5/289.abstract
AB Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition defined by somatic mutations in hematopoietic stem cells that result in clonal expansion, without overt hematologic malignancy. It is now recognized as a potent risk factor for atherosclerotic cardiovascular disease, with emerging associations across a broader spectrum of cardiovascular phenotypes, including myocarditis, pericarditis, arrhythmias, valvular heart disease, and heart failure. The authors of this article review the epidemiology, pathophysiology, and management of this condition.