RT Journal Article
SR Electronic
T1 Role of uric acid in hypertension, renal disease, and metabolic syndrome
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 1059
OP 1064
VO 73
IS 12
A1 Heinig, Marcelo
A1 Johnson, Richard J.
YR 2006
UL http://www.ccjm.org/content/73/12/1059.abstract
AB Hyperuricemia has long been known to be associated with cardiovascular disease, and it is particularly common in people with hypertension, metabolic syndrome, or kidney disease. Most authorities have viewed elevated uric acid as a secondary phenomenon that is either innocuous or perhaps even beneficial, since uric acid can be an antioxidant. However, recent experiments have challenged this viewpoint. In this paper we argue that uric acid is a true risk factor for cardiovascular disease. Furthermore, we suggest that the recent increased intake in the American diet of fructose, which is a known cause of hyperuricemia, may be contributing to the current epidemic of obesity and diabetes.